Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

BACKGROUND To test whether a site-specific hysteroscopic biopsy-induced injury in the endometrium during the controlled ovarian hyperstimulation cycle improves subsequent embryo implantation in patients with repeated implantation failure, a total of 30 patients who have had good responses to controlled ovulation stimulation but have failed to achieve pregnancy after two or more transfers of goo...

Accuracy of Two-Dimensional Transvaginal Sonography and Office Hysteroscopy for Detection of Uterine Abnormalities in Patients with Repeated Implantation Failures or Recurrent Pregnancy Loss

Objective: to compare diagnostic values of two dimensional trans-vaginal sonography (TVS) and office hysteroscopy (OH) for evaluation of endometrial pathologies in cases with repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). Methods and Materials: This prospective study was performed in Royan institute from December 2013 to January 2015. TVS was performed before hysteroscop...

Endometrial MicroRNA Signature during the Window of Implantation Changed in Patients with Repeated Implantation Failure

BACKGROUND At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA (miRNA) signatures for impaired endometrial receptivity by microarray analysis. METHODS A total of 12 repeated implantation failure (RIF) patients and 10 infertile patients, w...

Endometrial cell specific gene activation during implantation and early pregnancy.

Human endometrium expresses numerous genes to achieve an optimal uterine environment for implantation and maintaining the pregnancy. In this review, we will summarize our previous observations on progestin regulated gene expression, estrogen metabolic enzymes, nitric oxide synthase, aromatase, IGF-I and II, IGFBP-1, prolactin and glycodelin. These genes are differentially activated in two types...

Hysteroscopic Findings in Patients with A History of Two Implantation Failures Following In Vitro Fertilization